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David C Seldin Selected Research

Immunoglobulin Light Chains (Immunoglobulin Light Chain)

12/2020Doxycycline decreases amyloidogenic light chain-induced autophagy in isolated primary cardiac myocytes.
1/2017A phase 1/2 study of the oral proteasome inhibitor ixazomib in relapsed or refractory AL amyloidosis.
9/2016Depression and anxiety in patients with AL amyloidosis as assessed by the SF-36 questionnaire: experience in 1226 patients.
11/2014Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity.
9/2013Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity.
5/2013Melphalan, lenalidomide and dexamethasone for the treatment of immunoglobulin light chain amyloidosis: results of a phase II trial.
3/2013Circulating matrix metalloproteinases and tissue inhibitors of metalloproteinases in cardiac amyloidosis.
1/2013Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience.
12/2012Amyloid deposits in the bone marrow of patients with immunoglobulin light chain amyloidosis do not impact stem cell mobilization or engraftment.
9/2012Multiple arterial and venous thromboembolic complications in AL amyloidosis and cardiac involvement: a case report and literature review.
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David C Seldin Research Topics

Disease

53Immunoglobulin Light-chain Amyloidosis
01/2017 - 06/2002
32Amyloidosis
12/2020 - 06/2002
20Neoplasms (Cancer)
03/2016 - 08/2002
11Breast Neoplasms (Breast Cancer)
03/2016 - 11/2002
11Cardiomyopathies (Cardiomyopathy)
11/2014 - 06/2002
10Heart Failure
12/2020 - 03/2010
8Carcinogenesis
10/2008 - 09/2002
6Amyloid Plaque
01/2015 - 08/2008
5Paraproteinemias (Monoclonal Gammopathy)
12/2014 - 03/2003
3Cardiotoxicity
12/2020 - 07/2013
3Transthyretin-Related Hereditary Amyloidosis
01/2015 - 01/2013
3Multiple Myeloma
07/2013 - 03/2003
3Inflammation (Inflammations)
10/2011 - 07/2006
3Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
06/2005 - 09/2002
2Lymphoma (Lymphomas)
12/2014 - 05/2012
2Inborn Genetic Diseases (Disease, Hereditary)
12/2013 - 07/2011
2Mitochondrial Diseases (Mitochondrial Disease)
09/2013 - 10/2010
2Proteostasis Deficiencies
01/2013 - 12/2007
2Hemorrhage
09/2012 - 05/2007
2Disease Progression
11/2008 - 01/2004
1Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
01/2021
1Inflammatory Breast Neoplasms
03/2016
1Fatigue
01/2016
1Graft vs Host Disease (Graft-Versus-Host Disease)
08/2015
1Pain (Aches)
01/2015
1Hepatomegaly
01/2015
1Lymphadenopathy
12/2014
1Capillary Leak Syndrome
09/2014
1Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy)
12/2013
1Polyneuropathies (Polyneuropathy)
12/2013
1Hypertrophy
03/2013
1Abdominal Pain (Pain, Abdominal)
12/2012
1Sjogren's Syndrome (Sjogren Syndrome)
12/2012
1Edema (Dropsy)
12/2012
1Diarrhea
12/2012
1Familial Amyloidosis (Hereditary Amyloidosis)
12/2012

Drug/Important Bio-Agent (IBA)

34Amyloid (Amyloid Fibrils)IBA
12/2020 - 06/2002
23Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA
12/2020 - 03/2003
23Melphalan (Alkeran)FDA LinkGeneric
11/2015 - 06/2002
13Proteins (Proteins, Gene)FDA Link
11/2014 - 08/2002
11Prealbumin (Transthyretin)IBA
01/2016 - 08/2008
7Lenalidomide (CC 5013)FDA Link
07/2014 - 01/2007
6Dexamethasone (Maxidex)FDA LinkGeneric
01/2016 - 01/2007
6Phosphotransferases (Kinase)IBA
09/2009 - 09/2002
6beta CateninIBA
10/2008 - 08/2002
6NF-kappa B (NF-kB)IBA
12/2007 - 11/2002
5Casein Kinase II (Casein Kinase 2)IBA
01/2021 - 08/2002
5Immunoglobulins (Immunoglobulin)IBA
12/2016 - 12/2007
3Matrix Metalloproteinases (MMPs)IBA
12/2020 - 11/2008
3Bortezomib (Velcade)FDA Link
01/2017 - 12/2011
3Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA
03/2016 - 01/2005
3Biomarkers (Surrogate Marker)IBA
03/2016 - 05/2011
3CarcinogensIBA
03/2016 - 01/2005
3Brain Natriuretic Peptide (Natrecor)FDA Link
03/2013 - 11/2008
3Cytidine Monophosphate (CMP)IBA
03/2013 - 11/2008
3AgarIBA
12/2005 - 11/2002
3Cyclin D1IBA
11/2005 - 01/2005
2Doxycycline (Periostat)FDA LinkGeneric
12/2020 - 12/2011
2Protein Isoforms (Isoforms)IBA
12/2020 - 08/2008
2Tissue Inhibitor of Metalloproteinase-1IBA
03/2013 - 11/2008
2Muramidase (Lysozyme)IBA
01/2013 - 12/2012
2Amyloidogenic ProteinsIBA
12/2012 - 08/2008
2Peptides (Polypeptides)IBA
05/2012 - 08/2008
2Transcription Factors (Transcription Factor)IBA
10/2008 - 12/2005
2Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA
12/2007 - 01/2005
29,10-Dimethyl-1,2-benzanthraceneIBA
12/2007 - 11/2005
2Glycogen Synthase KinasesIBA
07/2005 - 09/2002
2Carrier Proteins (Binding Protein)IBA
06/2005 - 06/2003
1Matrix Metalloproteinase InhibitorsIBA
12/2020
1Autophagy-Related ProteinsIBA
12/2020
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
12/2020
1ixazomibIBA
01/2017
1Proteasome InhibitorsIBA
01/2017
1Cytochrome P-450 CYP1A1 (CYP1A1)IBA
03/2016
1Small Interfering RNA (siRNA)IBA
03/2016
1LigandsIBA
03/2016
1pomalidomideIBA
01/2016
1Pharmaceutical PreparationsIBA
01/2016
1SteroidsIBA
08/2015
1Blood Proteins (Serum Proteins)IBA
01/2015
1Alkaline PhosphataseIBA
01/2015
1EnzymesIBA
01/2015
1Immunoglobulin M (IgM)IBA
12/2014
1Sirolimus (Rapamycin)FDA Link
11/2014
1plerixaforFDA Link
09/2014
1Granulocyte Colony-Stimulating Factor (G-CSF)IBA
09/2014
1Diflunisal (Dolobid)FDA Link
12/2013
1CalciumIBA
09/2013
1p38 Mitogen-Activated Protein KinasesIBA
07/2013
1SB 203580IBA
07/2013
1Troponin IIBA
03/2013
1Metalloproteases (Metalloproteinases)IBA
03/2013
1Congo RedIBA
12/2012
1Bone Morphogenetic Protein 5IBA
12/2012

Therapy/Procedure

21Stem Cell Transplantation
11/2015 - 03/2003
13Therapeutics
12/2020 - 03/2003
8Drug Therapy (Chemotherapy)
09/2017 - 06/2002
6Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation)
06/2010 - 03/2003
2Aftercare (After-Treatment)
01/2009 - 01/2004
1Hematopoietic Stem Cell Mobilization
12/2012